Evaluation of Multiple Medication Exposures

Evaluation of multiple medication exposures concurrently using a novel algorithm

PI: Ravy Vajravelu, MD, MCSE
Funding Source: NIH/NIDDK
July 1, 2019 - March 31, 2024

Traditionally, research studying medications associated with diseases are limited to analyzing one medication at a time. This novel project will validate medication class enrichment analysis, a recently developed algorithm to study multiple medications simultaneously for association with a disease of interest. Validation of this method will allow researchers to use existing medical databases to more rapidly identify potential medication causes of emerging diseases and identify medications with unanticipated beneficial effects, allowing such medications to be repurposed for new indications. Specifically, this research will demonstrate medication class enrichment analysis (MCEA) as a valid method for pharmacoepidemiology research, opening new research opportunities for the study of multi-exposure observational health databases (OHD).